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UNDERSTANDING FOOD ALLERGIES

The origins of many chronic health problems can be traced to compromised digestive functions.  Food allergies represent a chronic health problem of immense proportions.  Yet, as large as the problem is, food allergies continue to be poorly understood by doctors.

Causes of Food Allergies

In order to comprehend the complexity of food allergies it is first necessary to understand that food allergies result from:

          1) exposure to toxins

          2) intestinal permeability defects

          3) parasitic infections

          4) any combination of 1-3 above

It then makes perfect sense that the way to reduce or eliminate food allergies is to

          1) reduce exposure to toxins, endotoxins and xenobiotics (unnatural chemicals)

          2) correct and normalize gastrointestinal function by

                    a) improving digestion

                    b) removing toxins from the intestines

                    c) repairing and/or rebuilding the mucosal lining of the intestines

                    d) reducing oxidative damage

                    e) re-establishing the normal flora of the intestines

                    f) eliminating intestinal pathogens

          3) support detoxification

          4) eliminate parasites

1.  Reducing Exposure to Xenobiotics.

It is almost incomprehensible that food manufacturers utilize more than 3,500 different chemicals to prepare or process our foods.  The immensity of this number is underscored by the realization that the typical American diet contains less than 100 different food items.  The average person is hard pressed simply to name a hundred different foods!  Even with the opportunity to prepare lists of all the food stuffs eaten, chances are excellent that the total number of foods listed will fall far short of 1,000. 

And if that weren't incomprehensible enough, there are an additional 12,000 chemicals used in food packaging materials!  This is a staggering number of chemicals.  In total then, just to process, manufacture and package the foods we eat,  nearly 16,000 different chemicals are used!

The first question that comes to mind is "Have we taken leave of our senses?"  Or the question might be in the form of "What in the world are we doing to ourselves?"  If you are more familiar with the problem, the question might be phrased more like "When are we going to stop the chemical industry and its powerful lobby from contaminating our food chain?"  Or, if your perception of reality shifts more toward reliance on the medical establishment for the care of your health, you might ask "Why doesn't our Surgeon General bring this mass poisoning to an end?"

Newspaper and magazine articles blandly state that our bodies are exposed to many foreign chemicals daily.  To most people the term "many foreign chemicals" becomes meaningless.  Being meaningless, it is both ignored and quickly forgotten.  To the better educated "many" rarely translates to more than several dozen chemicals.  Having failed to get their attention, virtually no one is aware of the staggering contamination of our food chain. 

As might be expected there are few journalists writing about this disturbing state of affairs.  But of the few who do write, even fewer really understand the full impact of what they are writing about.  For example, Dr. Charles Walters, one of the nation's foremost authorities on the subject of food contamination recently stated "The average adult in the United States has been exposed to synthetic chemicals in the food supply for twenty to forty years.  At only twenty years of exposure, you're very likely to have one part per trillion dioxins in your system.  Doesn't sound like much, but it's enough to trigger any allergy problem known.  By the year 2008, the entire population will have been exposed to agricultural contamination with dioxins and other synthetic agricultural chemicals for sixty years, and we will have a pandemic of allergy and ill health unlike anything we've ever seen.  Prior to World War II, approximately one person in three hundred had chemically-induced allergy.  Now, it's one in three, and many don't even know that dioxins and other agricultural chemicals are causing their health problems!" (Charles Walters, Nutrition & Healing, Jan. 1996, pp 5-6).

We are watching the unfolding of a catastrophe.  Studies have shown that the total load of toxins to which we are exposed is inversely related to our ability to detoxify them.  Some of the xenobiotics we are unable to detoxify by normal mechanisms and as a result, they remain in our bodies almost indefinitely.  For example, our bodies cannot detoxify Freon, a common CFC used in refrigerators, freezers and air conditioners.  To be sure, thousands of refrigerators leak Freon and other refrigerants each year.  And because people breath the air in their homes, hundreds of thousands of people absorb this Freon and other CFCs.  Similarly, mechanics working on automobile air conditioning systems are routinely exposed to high levels of these dangerous gases.  Once absorbed, these gases are there to stay.  There is no natural way out!  Our livers are unable to detoxify them.  Special procedures are required to eliminate these deadly toxins and allopathic physicians are unaware of their existence.  This assumes also that someone (a competent medical professional) will test and/or detect Freon as a problem. 

Thus, perhaps the most important key to the restoration of health is to reduce our  exposure to toxins.  And the best place to start is to attack the most common source of exposure -- our foods.

2.  Normalizing Gastrointestinal Function

a)  Improving Digestion

Deficiencies of digestive enzymes and imbalances in gastrointestinal pH are common causes of impaired digestion.  Impaired digestion then contributes to the improper absorption of nutrients, food intolerance, food allergies and the formation of endotoxins. 

Improperly digested foods or incompletely digested foods will undergo putrefaction (rotting) or fermentation (producing alcohol and gas) and always results in the creation of endotoxins.  All undigested dietary proteins and large polypeptides can have significant allergenic potential both in the gut and throughout the body.

Thorough digestion reduces allergic reactions to foods and reduces the production of endotoxins.  It is therefore necessary to take proteolytic enzymes (protein-breaking enzymes) to break down protein-based foods.  This eliminates or greatly reduces protein-based food antigens.  It is important to understand that pH-sensitive enzymes such as pancreatin and pepsin may be INACTIVE in people with gastric or pancreatic hypofunction.  But plant enzyme preparations are active and stable in both acid and alkaline conditions.

Other factors are also involved in digestive function.  The first absolute factor is chewing.  Chewing is indispensable for good digestion.  Eating while relaxed is also of critical importance.  Too many people eat on the run, eat standing up, or eat while in a car.  Stop these practices and eat only while relaxed.  Failure to do so will only prolong the problems of food allergies.  Also eating plenty of raw foods is important.  Raw foods are particularly rich in digestive enzymes.

b)  Removing Intestinal Toxins

Dietary fiber and its metabolic products are very important.  Both soluble and insoluble components are absolutely necessary to colon health.  Soluble fiber is fermented by colon microflora to short chain fatty acids (SCFAs) such as butyric acid.  Butyric acid is the preferred fuel source for the colon's mucosal cells.  Butyric acid is also metabolized to glutamine which is essential to fuel the cells of the small intestine.  Fiber has also been shown to restore the normal shape and function of the villi.  In the absence of adequate amounts of fiber, the intestinal bacteria will translocate. 

Fiber prevents chronic and degenerative diseases.  Current guidelines advise doubling fiber intake of all Americans.  Excellent sources of soluble fiber include psyllium, oat products, guar gum and certain fruits and vegetables.  Plant foods provide insoluble fiber.  In addition to promoting beneficial SCFA production, and intestinal motility, dietary fiber also helps bind endotoxins.  The oral use of bentonite helps bind endotoxins and prevents their systemic absorption.

c)  Rebuilding Intestinal Mucosa

Imagine a magic strainer or sieve that selectively allows certain good things to pass through it while filtering out small, medium or large bad things.  It is much like the muscles of the anus relaxing just enough to allow any size waste material to pass out.  The healthy lining of the intestine is just like a magic sieve.  It is selectively permeable, acting as an absorption surface for nutrients and a barrier which prevents harmful compounds from entering the body.  However, when the mucosa becomes damaged or diseased, its magic disappears.  Without magic, bacteria, toxins, antigens and other noxious compounds from the intestines can be absorbed.

Leaky gut syndrome (LGS) represents the most severe state of damaged mucosa.  In LGS, antigenic macromolecules and other harmful substances gain access to the circulation.  Antigenic compounds cause local and system wide allergic responses by stimulating the production of antibodies.  These antibodies then cross react with immunologically similar tissues. 

Research has shown that certain autoimmune diseases are caused by this immunological cross reaction method.  For example, inflammatory bowel disease, food allergies, rheumatoid arthritis, ankylosing spondylitis, chronic hepatitis, celiac disease and Reiters Syndrome are all associated with antigen uptake from the intestines. 

To illustrate the problems of antigen uptake from the intestines consider what would happen to your body if you tried to inject milk directly into the muscle or vein.  You would develop a massive reaction to the raw proteins, fats, carbohydrates and other ingredients in the raw milk.  The milk must be digested (broken down) before the body can use it.  It is then easy to understand that in leaky gut syndrome, partially digested foods actually gain access to the general circulation.  These partially digested foods act as antigens and cause the body to respond with a massive antibody response.  Antibodies are the body's way of protecting itself from foreign substances.  These antibodies are powerful destroyers of antigens and will even destroy the cells that harbor such antigens.  As a result, many tissues become damaged and inflamed due to the antigen-antibody responses that occur just due to absorption of partially digested foods. 

Next look at what happens when you aggravate this condition with parasites.  This is not a fantasy.  More than 90 percent of the adult population of the United States is infected with parasites.  Parasitic worms usually live in the intestines but can and often do move at will throughout the body.  However, while they are in the intestines, these parasites for the most part have no choice but to eat what ever happens to come through the intestines.  Some suck blood (i.e. hookworms) but most eat food stuffs (you or your food).  When a worm eats the partially digested food substances present in your intestines and then gains access to the general circulation, this worm may be accidentally carrying potent food allergens into remote tissues.  Such may be the case when the roundworm Ascaris carries wheat protein into joint tissues.  If the worm defecates in the joint, the body's antibody system will attack both the worm waste and the allergenic food stuffs present therein.  The result is swelling and inflammation which can go on for long periods of time leading to rheumatoid arthritis. 

It makes no difference whether the food antigen gained access of its own accord or in Trojan Horse fashion (i.e. riding inside a parasitic worm), the results are always the same.  If the food antigen happens to be absorbed by cells before the antibodies can destroy it, then the antibodies will simply penetrate the cell and destroy it in the process of destroying the antigen.

Now it is easy to understand the tremendous importance of the gut in preventing crippling and painful diseases like rheumatoid arthritis.  And it should be just as easy to understand that food allergies are the result of the same mechanisms: foods that are not completely digested gain access to the systemic circulation, become antigens and trigger antibody production and can trigger allergic shock in extreme cases.  Between these extremes one can see symptoms as diverse as itching, reddening of the skin, to epileptic seizures and severe mental disturbances. 

The gut is considered the largest immune organ in the body.  When the intestinal mucosa is disturbed or disrupted the result is 

          1) impaired digestive and absorptive functions and

          2) vital immune responses are compromised leading to food allergies, etc.

Gut-associated lymphatic tissue (GALT) gives your body specific immunity in the form of secretory immunoglobulin-A ( sIgA ) while specialized cells in the mucosa (such as macrophages, natural killer cells, mast cells and intraepithelial lymphocytes) protect against the absorption of intestinal toxins and pathogens.

Non-specific immunity helps these specific immune system entities in that the work load is greatly reduced.  Non-specific immune mechanisms include gastric acidity, mucus, motility, digestive enzymes and normal bacterial flora. 

The more common causes of permeability defects include the use of alcohol and non-steroidal anti-inflammatory drugs (NSAIDs).  Intestinal parasites, dysbiosis, impaired digestion, pancreatic insufficiency and food allergies also contribute.  Permeability defects are also associated with inflammatory bowel disease, post-surgical trauma, extended immobility, prolonged fasting and starvation, certain autoimmune diseases, AIDS and AIDS Related Complex (ARC) and other environmental illness.

Re-establishing a healthy intestinal lining with an intact physical and immune barrier requires the presence of nutrients that act as intestinal cellular fuels and mucosal building blocks.  Glutamine is a key fuel for the cells of the small intestine, or enterocytes.  Considered a conditionally essential amino acid, L-glutamine is required for normal structure and barrier function of the small intestine.  Additionally, L-glutamine will also overcome depression and bring about an enhanced release of human growth hormone. 

Other nutrients, such as N-acetyl-D-glucosamine, support normal mucosal secretion, being a constituent of the most superficial mucosal layer known as the glycocalyx.  Gamma-linolenic acid (GLA) stimulates the production of the E series prostaglandins which have been shown to reduce both intestinal permeability and inflammation.  Gamma oryzanol, a component of rice bran oil, has been shown to reduce small bowel ulcer formation and to have antioxidant effects on the gastrointestinal mucosa.  Phosphatidyl choline has been shown to support normal mucosal barrier function. 

d)  Reducing Oxidative Damage

Free radicals, or pro-oxidants, have been implicated in the development of over 50 human diseases including chronic inflammatory bowel disease and bowel cancer.  Oxidative stress occurs when the antioxidant/pro-oxidant equilibrium becomes imbalanced.  Once antioxidant stores are depleted, oxidative stress in the gastrointestinal tract results in tissue damage and inflammation, and has been implicated in malignant transformation.

Antioxidant depletion can occur as a result of tissue damage from disease or injury, exposure to environmental pollution and radiation, chronic drug and alcohol use, the use of NSAIDs and antibiotics, unnecessary iron supplementation and numerous other causes.  Intestinal pathogens and dysbiosis can also contribute to antioxidant depletion both directly and by the production of endotoxins. 

Several antioxidants have been shown to be effective in preventing damage due to free radicals.  Glutathione and glutathione precursors such as N-acetylcysteine, vitamin E, vitamin C, beta carotene, and selenium are among the most widely researched of the natural antioxidants.  Potent phytochemical antioxidants are also found in plant flavonoids such as quercetin and ginkgo flavone glycosides.  Research indicates that quercetin acts to stabilize intestinal mast cell membranes, thus inhibiting the release of histamine and other inflammatory mediators.  Ginkgo flavone glycosides have been shown to exert direct antioxidant effects on the gastrointestinal mucosa and to improve circulation.

e)  Re-establishing Normal Flora

Normal bowel flora help to prevent the establishment of intestinal pathogens through competitive inhibition.  Beneficial bacteria or probiotics, such as Lactobacillus and Bifidobacteria species, contribute to a healthy intestinal environment by maintaining optimum pH and producing important nutrients and certain enzymes.  In addition, Lactobacilli produce natural antibiotics and other antimicrobial substances that suppress the growth of pathogenic organisms and reduce putrefaction and endotoxemia.  Both Lactobacilli and Bifidobacteria are known to have beneficial immunological effects by reducing production of procarcinogens and inducing large increases in sIgA production.

Indigenous flora play an important role in immune homeostasis.  Interactions of intestinal microflora with GALT (gut-associated lymphatic tissue) and the liver play an important role in overall immunocompetence.  Healthy bacterial microflora are required for maturation of the intestinal immune system, whereas translocation of pathogenic microorganisms has been shown to suppress T-cell formation and to alter immune function of the liver. 

Research indicates oral preparations of probiotic bacteria and microflora growth promoters such as fructooligosaccharides (FOS) can play a significant role in re-establishing the natural balance of healthy bowel flora.  Human studies have shown significant increases in populations of beneficial Bifidobacteria following oral administration of short-chain FOS.  Lactobacillus and Bifidobacterium species along with S. faecium constitute an integral part of the healthy intestinal microecology.

f)  Eliminating Intestinal Pathogens

 Detection and elimination of intestinal pathogens are key steps to re-establishing a healthy gastrointestinal tract.  Dysbiosis, candidiasis and the presence of intestinal parasites have been linked to a number of chronic illnesses.  Pathogenic E. coli, Enterobacter, Klebsiella, Pseudomonas, Sertia and Bacteroides are common intestinal pathogens which are often involved in endotoxemia.  Endotoxins can cause local and systemic inflammation via activation of the alternate complement pathway and have been implicated in the development of psoriasis, systemic lupus erythematosis, dermatomyositis, pancreatis and other chronic disorders. 

Cross reactivity of bacterial antigens to normal human tissues is one mechanism by which intestinal pathogens can contribute to the development of chronic degenerative disease.  Studies indicate ankylosing spondylitis and other diseases associated with HLA-B27 may develop in response to an antigenic trigger acting across a mucous membrane, such as that of the gut mucosa.  Intestinal pathogens have been implicated in cases of diabetes myelitis, ulcerative colitis, thyroid disease and other disorders.

Active principles from the Artemesia annua shrub, green black walnut hull , freshly ground cloves and others are used worldwide for the treatment of protozoal diseases, nematode and other roundworm diseases as well as fluke diseases. 

 

2.  Supporting Detoxication

Phase I and Phase II Nutrients

The liver is the principal organ responsible for detoxifying xenobiotics and endotoxins which enter the general circulation. This is accomplished by Phase I and Phase II detoxication reactions which occur in the liver's hepatocytes.  These biotransformation reactions convert toxins which are fat soluble and difficult for the body to eliminate into water-soluble metabolites which are generally less toxic and easier to eliminate. 

Phase I reactions are principally catalyzed by the cytochrome P-450 enzyme system.  Cytochrome P-450 reactions generate free radicals which can cause secondary damage to vital cell macromolecules such as mitochondrial enzymes, microsomal membranes and DNA.  An adequate supply of key antioxidants and free radical quenchers is required to prevent this secondary tissue damage.  Reduced glutathione, superoxide dismutase and catalase comprise the body's primary intracellular defense against free radicals.  Additional nutrients which function as antioxidants include beta carotene, vitamin E, selenium and N-acetylcysteine.  Other vitamin and mineral cofactors required for cytochrome P-450 mediated reactions include riboflavin, niacin, magnesium, iron and a number of trace minerals.  Certain phytochemicals such as indoles from cruciferous vegetables and quercetin have also been shown to support Phase I detoxication.

For many chemicals, Phase I reactions generate highly toxic intermediates which are more harmful than the parent compound.  These must undergo Phase II conjugation reactions to prevent them from reacting with vital cell macromolecules and causing severe tissue injury, immunologic damage or mutation.  Glutathione conjugation is the primary pathway for detoxication of such "bioactivated" intermediates.  Increased exposure to toxins (and decreased supplies of precursors needed for glutathione production) can lead to glutathione depletion and increased damage from these reactive intermediates.  Oral supplementation with reduced L-glutathione and N-acetylcystein have each been shown to increase glutathione levels in vivo.

Phase II conjugation reactions combine toxins or reactive intermediates with endogenous conjugating agents to make them less toxic and more easily eliminated.  Conjugation with glucuronic acid is the most common Phase II reaction.  Beta-glucuronidase, an enzyme produced by intestinal bacteria, reverses the glucuronidation reaction and releases previously conjugated toxins to be re-absorbed from the gut, resulting in increased toxicity.  Studies have shown that calcium d-glucurate, a natural ingredient in certain vegetables and fruits, inhibits microbial beta glucuronidase activity, resulting in decreased absorption and increased elimination of toxins.  Other conjugating agents which play a vital role in Phase II pathways include amino acids such as glycine, cysteine, glutamine, methionine, taurine, glutamic acid and aspartic acid. 

The liver is equipped to handle the levels of endotoxin production that occur as a result of normal digestion, elimination, fighting infections and dealing with stress.  However, the additional load that occurs as a result of xenobiotic exposure compounded by permeability defects, dysbiosis, intestinal parasites or food allergies can overwhelm the detoxication pathways and deplete much needed stores of antioxidants, conjugating agents and nutritional precursors, ultimately compromising the health of the whole person.  Dietary supplementation can help to replace depleted supplies of nutrients needed for detoxication.

NUTRITIONAL SUPPORT FOR G.I. AND LIVER FUNCTION IN

LEAKY GUT SYNDROME - THE BASE PROBLEM IN FOOD ALLERGIES

Because Leaky Gut Syndrome is the basis of most disturbed gut and G.I. functions, it is desirable to correct even the slightest disturbances in function in all the organs involved.  Beginning with the stomach it is best to assist the digestive process with dietary enzymes.  This program of nutritional support for the gastrointestinal and hapatic systems should be undertaken only after the home colonic intestinal cleanse has been completed and after the parasite cleanse has been underway for at least one week.  

1.  Take 1 Similase® capsule 3 times daily at the beginning of meals.     CAUTION:  If you are suffering from or have been diagnosed as having gastritis, gastric or duodenal ulcers do not use Similase®. 

Similase® is a highly concentrated plant enzyme digestive formula designed for persons on an average mixed diet containing carbohydrade, protein, fat, fiber and dairy products.   

2.  Antigen "sampling" seems to be a function of the sub-epithelial immune tissue in the small and large intestines.  This "sampling" activity helps to program the body's defenses and protect against exposure to "foreign" dietary proteins and polypeptides.  Under pathological conditions (i.e. any stage of the leaky gut syndrome) food allergies can be caused by several factors, including increased supply of dietary antigens which leak into the bloodstream as a result of inadequate protein digestion. 

Fungal enzymes like Gamma Oryzanol digest dietary protein when administered orally at mealtime.  This helps to decrease the supply of antigenic macromolecules available to leak into the blood stream.  In addition, orally administered fungal enzymes which have, themselves, been absorbed intact may help to "digest" antigenic dietary proteins which they encounter in the blood stream.

Take 2 Gamma Oryzanol capsules daily at each meal during first month.

Take 1 Gamma Oryzanol capsule daily at each meal during second month.

Thereafter take 1 Gamma Oryzanol daily at any time.   

3.  It is impossible to overstate the necessity of reestablishing normal beneficial bacteria populations in the intestines.  The best policy is provide diverse forms of beneficial bacteria in the nutritional support program. 

Take 4 Enterogenic® capsules twice daily between meals with at least 8 oz of pure drinking water.  This will supply your system with 4,800 mg of fructooligosaccharides (FOS), a food stuff you don't absorb but which enables beneficial bacteria to fluorish.  These capsules will also provide you with more than 6 billion viable organisms including Lactobacillus acidophilus, Bifodobacterium bifidum, B. infantis, and Streptococcus faecium.  Beneficial bacteria are essential to controlling Shigella which are found in all MS patients. 

4.  Candida is one of the most troublesom of the intestinal pathogens.  It is necessary to control this yeast in order to regain normal intestinal function. Candida Complex® is a balancing formula designed to bring Candida under control by supplying viable probiotic intestinal microflora. 

Take 2 Candida Complex® capsules between meals 3 times daily.

5.  The intestines retain vast amounts of toxins when normal functions are disturbed.  These toxins must be removed if there is to be any hope of recovering from the diverse ravages of LGS.  This process is best begun through products that absorb intestinal toxins. 

Take 6 Fiber Formula® capsules on an empty stomach with a large glass of water.  Repeat twice daily.  This will provide psyllium hull powder, oat bran, bentonite powder, bromelain (a digestive aid), papain, guar gum, marshmallow root, prune powder, vitamin C, Echinacea, Goldenseal, Cranesbill and Ginger root.

6.  It is probable that in most cases of Leaky Gut Syndrome involving food allergies heavy metal poisoning is involved.  Heavy metals create massive amounts of tissue damage through their ability to generate free radicals.  Free radicals are easily as damaging as radiation, if not more so.  It becomes necessary to reduce oxidative damage.

Oxyperm®, is a targeted antioxidant support for the gastrointestinal mucosa.  This product supplies quercetin, ginko flavone glycosides, N-Acetyl-L-Cystein, beta carotene, selenium and vitamins C, E and zinc.      

Take 1 to 2 Oxyperm® capsules with meals three times daily. 

7.  Mercury is a known cytotoxin and a naturally occurring heavy metal present in the environment.  Mercury toxicity causes intracellular glutathione depletion, resulting in lipid peroxidation, DNA damage and altered calcium and sulfhydryl homeostasis.  The tissues most susceptible to this oxidative damage are primarily the kidney and central nervous system.  Mercury accumulation in these organs has been shown to occur even with low dose exposure.  Recent studies suggest that low dose mercury can deplete mitochondrial glutathione and enhance hydrogen peroxide formation.  In addition, mercury has been shown to inhibit the host defense system in general the immune system in particular.  This is critical importance in food allergies. 

Take 2 Mercury Detox® capsules on an empty stomach twice daily.

8.  Mixtures of Reduced Glutathione and anthocyans show powerful heavy metal chelating effects.  Use Recancostat® in association with any heavy metal detox program.

Dissolve 1 capsule of Recancostat® under the tongue daily. 

   

9.  The intestinal mucosa needs to be nourished if one is ever to overcome the ravages of LGS.  Permeability Factors® is a product designed to supply nutritional support to the mucosa. 

Take 2 Permeability Factors® capsules 3 times daily between meals.

10.  The liver is overworked in all cases of Leaky Gut Syndrome and food allergy states.  Accordingly, the liver must be supplied with nutrients essential to phase I and II liver detoxication.  Without the proper supply of antioxidants to the liver, the production of free radicals can cause damage as the liver works to detox chemicals and toxins.  It is important to understand that free radicals are created naturally by the liver during all detox reactions.     

Take 2 Detoxication Factors® capsules 3 times daily between meals. 

11.  Additional protection for stressed livers is provided by Silybum marianum extract and nutritional methyl donors.  Hepatic Complex® is a standardized Silybum marianum extract (80% Silymarin) combined with plant enzymes and botanical synergists. 

Take 2 Hepatic Complex® capsules between meals 3 times daily.

Take 1 Lipotropic Complex® capsule 2 times daily with meals.

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